Advanced glycation end-products (AGEs) are formed in vivo from the nonenzymatic reaction between sugars and proteins. AGEs accumulate in long-lived tissues like tendons, cross-linking neighboring collagen molecules, and are in part complicit in connective tissue pathologies experienced in aging Nurse Cosmos Seeds Dickhead Dog Shirt and with diabetes. We have previously described discrete plasticity: a characteristic form of nanoscale collagen fibril damage consisting of serial fibril kinking and collagen denaturation that occurs in some mechanically overloaded tendons. Excessive iron loading may cause skeletal muscle atrophy and weakness because of its free radical generating properties.
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To determine whether a clinically relevant degree of iron loading impairs skeletal muscle function, young male mice received injections of iron dextran. We suspect that this failure mechanism may be an adaptive trait of collagen fibrils and have published evidence that inflammatory cells may be able to recognize and digest the denatured collagen produced by overload. In this study, we treated bovine tail tendons with ribose to simulate long-term AGE cross-linking in vitro. We hypothesized that a high degree of cross-linking would inhibit the intermolecular sliding thought to be necessary for discrete plasticity to occur. Tendons Nurse Cosmos Seeds Dickhead Dog Shirt were mechanically overloaded, and properties were investigated.
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